Applied Math Seminar-Computational Modeling of Cell Migration in Microfluidic Channel

Time: Thursday, Oct. 20th. 11:00 am-12:00 noon

Place: Phillips 730

Speaker: Zengyan Zhang, Utah State University

Title: Computational Modeling of Cell Migration in Microfluidic Channel

Abstract: Cell migration plays an important role in various biological processes, such as tissue morphogenesis, wound healing and cancer metastasis, etc.. The mechanisms underlying cellular motility involve generating protrusive patches on the moving interfaces and determining moving directions under the guidance of chemotaxis. In our work, we proposed a phase-field model coupled with a reaction-diffusion system to keep track of the morphology changes of the cell membrane and steer the cell by gradients of attractive chemicals. In this talk, I will introduce our phase-field model for the migration of cell through complex channels and some numerical simulation results will be elaborated. This is a joint work with Dr. Yanxiang Zhao from The George Washington University and Dr. Jia Zhao from Utah State University.