# Applied Mathematics Seminar

Department of Mathematics, Phillips Hall, 801 22nd Street NW, Washington, DC 20052.

CFall 2019ontact Maria Gualdani or Xiaofeng Ren if you need more information about the seminar.

**Fall 2019**

### "no current seminars"

**Past Talks**

**Spring 2019**

Title: The Mathematical Structure of Diabetes on a Slow Manifold

Speaker: Dr. Joon Ha

Affiliation: NIH and GWU

Date and Time:Monday, March 4, 4:00pm-5:00pm

Place: Rome 730

Abstract: Type 2 diabetes (T2D) is a chronic disorder in glucose homeostasis, caused by both genetic and environmental factors. A common form of pathophysiology of the disease is the failure of insulin-secreting pancreatic β-cells to increase levels of insulin, demanded mainly by obesity and aging. Such increased insulin levels are utilized to maintain a normal range of blood glucose concentration. Blood glucose sharply rises at the onset of the disease, as clinically observed, suggesting that there exists a threshold in glucose homeostasis. Using a model of T2D pathogenesis, we found that the threshold is not solely determined by glucose concentration, but corresponds to the crossing of a separatrix in the plane of insulin sensitivity and beta-cell mass, which is the phase plane of the slow subsystem of the model. The product of sensitivity and mass corresponds to the disposition index (DI), which is frequently used in clinical trials to quantify diabetes risk. This finding highlights that a dynamic interaction of insulin secretion and sensitivity plays a major role in progression to diabetes. Furthermore, the threshold formed in the DI plane addresses well how both genetic and environmental factors contribute to developing diabetes. These insights will aid in applying the mathematical model of progression to diabetes to clinical studies of personalized medicine.

Title: Nonparametric inference of interaction laws in systems of agents from trajectory data

Speaker: Ming Zhong

Affiliation: Johns Hopkins University

Date and Time:Monday, February 25, 3:30pm-4:30pm

Place: Rome 730

Abstract. Inferring the laws of interaction between particles and agents in complex dynamical systems from observational data is a fundamental challenge in a wide variety of disciplines. We propose a non-parametric statistical learning approach to estimate the governing laws of distance-based interactions, with no reference or assumption about their analytical form, from data consisting trajectories of interacting agents. We demonstrate the effectiveness of our learning approach both by providing theoretical guarantees, and by testing the approach on a variety of prototypical systems in various disciplines. These systems include homogeneous and heterogeneous agents systems, ranging from particle systems in fundamental physics to agent-based systems modeling opinion dynamics under the social influence, prey-predator dynamics, flocking and swarming, and phototaxis in cell dynamics.

Title: Primal-Dual Weak Galerkin Finite Element Methods for PDEs

Speaker: Chunmei Wang

Affiliation: Texas Tech University

Date and Time:Monday, January 14, 11:00am-12:00pm(**RESCHEDULED FOR TUESDAY JANUARY 15, 2019 FROM 11AM-12PM DUE TO SNOW DAY ON MONDAY)**

Place: Rome 771

Abstract. Weak Galerkin (WG) finite element method is a numerical technique for PDEs where the differential operators in the variational form are reconstructed/approximated by using a framework that mimics the theory of distributions for piecewise polynomials. The usual regularity of the approximating functions is compensated by carefully-designed stabilizers. The fundamental difference between WG methods and other existing finite element methods is the use of weak derivatives and weak continuities in the design of numerical schemes based on conventional weak forms for the underlying PDE problems. Due to its great structural flexibility, WG methods are well suited to a wide class of PDEs by providing the needed stability and accuracy in approximations. The speaker will present a recent development of WG, called "Primal-Dual Weak Galerkin (PD-WG)", for problems for which the usual numerical methods are difficult to apply. The essential idea of PD-WG is to interpret the numerical solutions as a constrained minimization of some functionals with constraints that mimic the weak formulation of the PDEs by using weak derivatives. The resulting Euler-Lagrange equation offers a symmetric scheme involving both the primal variable and the dual variable (Lagrange multiplier). PD-WG method is applicable to several challenging problems for which existing methods may have difficulty in applying; these problems include the second order elliptic equations in nondivergence form, Fokker-Planck equation, and elliptic Cauchy problems. An abstract framework for PD-WG will be presented and discussed for its potential in other scientific applications.