Date: Friday Feb. 17th at 3:00-4:00 pm EST
Place: Zoom https://gwu-edu.zoom.us/j/95224177633
Speaker: Huijing Du (University of Nebraska-Lincoln)
Title: Multiscale modeling of epidermal-dermal interactions during skin wound healing
Abstract: Following injury, skin activates a complex wound healing program. While cellular and signaling mechanisms of wound repair have been extensively studied, the principles of epidermal-dermal interactions and their effects on wound healing outcomes are only partially understood. We developed a multiscale, hybrid mathematical model of skin wound healing. The model takes into consideration interactions between epidermis and dermis across the basement membrane. Simulations revealed that epidermal-dermal interactions are critical for proper extracellular matrix deposition in the dermis, suggesting the important role of signaling across dermal-epidermal interface and the effect of fibrin clot density and wound geometry on scar formation.