Applied Math Seminar-  From Gene Editing to Genome Function

Speaker: Dr. Wei Li (University of Maryland, School of Medicine)

Title: From Gene Editing to Genome Function

Date and Time: Friday, April 4, 2 pm-3pm

Place: Phillips Hall 730

Abstract: Genome engineering (e.g., CRISPR system) has become a fundamental technology in biology, but many interesting and important computational problems exist. Here I will introduce our lab’s recent computational work on genome engineering and functional genomics. First, I will present our machine learning approaches to model the efficiency and specificity of various gene editing tools (e.g., Cas13, base editing). Second, I will present our recently published perturbation-response score (PS) method to model the heterogeneity of single-cell responses to perturbations. We will highlight some of the novel biological findings based on our models.